Blog entry by Meguid El Nahas
Anyone in the world
I read more than once this paper and failed to understand it...
N Engl J Med. 2017 Jun 15;376(24):2349-2357. doi: 10.1056/NEJMoa1614329.
Single-Nephron Glomerular Filtration Rate in Healthy Adults.
Denic A1, Mathew J1, Lerman LO1, Lieske JC1, Larson JJ1, Alexander MP1, Poggio E1, Glassock RJ1, Rule AD1.
Total measured GFR doesnt seem to change much with age...
Age related reduction in Nephron numbers doesnt seem associated with compensatory growth of remnant nephrons...not surprising, well known in animal models of renal mass reduction that compensatory renal growth is blunted with age!
Nephrosclerosis associated reduction in nephron numbers is associated with compensatroy glomerular growth, that maintain total GFR; well thats good news and shows that compensatory growth and hyperfiltration are a good and not a bad thing...physiological rather than pathological as we were led to beleive...
Obesity and excessive height are associated with single nephron hyperfiltration...so what...?!
Overall, I failed to quite grasp the publication message,
CAN SOMEBODY EXPLAINS ITS FINDINGS TO ME....?!
[ Modified: Thursday, 1 January 1970, 1:00 AM ]