Blog entry by Meguid El Nahas
Trachtman and colleagues report in the June 2011 issue of KI the outcome of the phase 1 study of fresolimumab, a human monoclonal anti-TGF-beta antibody in 16 patients with FSGS. Patients were divided into 4 groups receiving fresolimumab doses ranging from 1mg/k to 4mg/kg given as a single intravenous dose. Patients had detectable levels of circulating fresolimumab at day 112. Fresolimumab was well tolerated. This publication is the first report of the use of an anti-TGF-beta antibody in patients with CKD. The safety profile confirms that reported in trials of patients with pulmonary fibrosis and cancer. There was no evidence that the administration of fresolimumab adversely affecetd teh course of the FSGS. Undoubtedly, larger proof of concept, phase 2, trials of efficacy of this form of therapy in nephropathies will soon be underway.