Blog entry by Meguid El Nahas
What did I learn?
Dr Amy Jane McKnight (Winner of Raine Prize 2012):
Genetics of CKD and DN.
Identified an important genetic association between risk of Diabetic nephropathy, progression as well as tubulointerstitial fibrosis with mutations of the AFF3 gene. AFF proteins are localized in the nucleus and play a role as transcriptional activators with a positive action on RNA elongation and processing of RNA.
She also identified mutations of Haplogroup I on the Y chromosome to be associtaed with CKD as well as CVD in white europeans.
She stressed the potential for changes in DNA methylation on the Y chromosome in the predisposition to CKD.
Prof Jeremy Hughes (Edinburgh):
Gave an excellent talk on experimental ageing.
He highlighted the role of the RAAS in ageing; RAAS inhibition prolongs life span in rodents.
Mitochondrial RAS is mainly directed to the beneficial AT2R during early life and switch to AT1R with ageing. AT1R is linked to the generation of reactive oxygen species (ROS) and tissue damage. RAS blockade decrease ROS generation by mitochondria.
Prof Tom Kirkwood (Professor of ageing in Newcastle):
Reminded us that ageing is a human phenomenon, most other spoecies die before they get too old, excpet man who nowadays lives much longer without the genetic apparatus to prevent ageing. Humans dont have a genetic program for ageing, instead ageing is the direct results of cumulative daily genetic damage. Ageing is caused by damage in the absence of a genetic repair machinery.
Ageing is theresult of random molecular and gentic damage. Consequently, to this daily and random genetic mutations, none of the 100x100million cells in humans are alike as not two cells have the same genome due to endless somatic mutations. Also mtochondrial mutations increase with ageing.
No evidence that calorie restrictions prolongs lifespan in humans in spite of considerable data in rodents but conflicting data in non human primates.
Excercise prolongs lifespan...
Prof Jurgen Floege (Germany):
gave a lecture on vascular calcification in CKD.
Highlighted the protective role of matrix Gla protein (MGP). Warfarin decreases its levels and accelerates vasculkar calcifications.
He argued that Warfarin should not be used in ESRD patients as it often underly lifethreatening calciphylaxis.
He also argues that Vitamin K1 and K2 supplement may be protective against vascular calcification in ESRD. Vitamin K2 attenuates warfarin-induced vascular calcification in experimental models.