Sleep-Time Hypertension: A major CKD-CVD Risk Factor

Written by Meguid El Nahas on Thursday, 26 October 2017. Posted in OLA Blog

Sleep-Time Hypertension: A major CKD-CVD Risk Factor

the MAPEC spanish propsective study of ~5,000 individual showed that sleep-time hypertension rather than casual-clinic BP or 24h ABPM was the independent risk factor for incident CKD.

Previous studies highlighted the prognostic relevance of sleep time systolic BP to the development of CVD; Consistent evidence of numerous studies substantiates the asleep blood pressure (BP) mean derived from ambulatory BP monitoring (ABPM) is both an independent and a stronger predictor of cardiovascular disease (CVD) risk than are daytime clinic BP measurements or the ABPM-determined awake or 24-hour BP means.

More attention needs therefore to be paid timely and adequate measure of BP in the population at a whole but also those at risk of CVD and CKD; the older population.

Consequently, more attention needs to be paid to the timely, evening, administration of anti-hypertensive medication. Chronotherapy improves hypertension management and its complications.

Nephrologists and general practitioners need to shift their management paradigm to a focus on bedtime, sleep BP monitoring as well as evening, bedtime, ingestion of the full daily dose of at least one antihypertensive agent.


Meguid El Nahas

Professor Meguid El Nahas PhD, FRCP

Chief Editor, OLA Director

Professor El Nahas was born in Cairo, Egypt and undertook his undergraduate medical education in...

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