More or Less Nephrons...

Written by Meguid El Nahas on Thursday, 22 June 2017. Posted in OLA Blog

More or Less Nephrons...

I read more than once this paper and failed to understand it...

N Engl J Med. 2017 Jun 15;376(24):2349-2357. doi: 10.1056/NEJMoa1614329.

Single-Nephron Glomerular Filtration Rate in Healthy Adults.

 
Total measured GFR doesnt seem to change much with age...
 
Age related reduction in Nephron numbers doesnt seem associated with compensatory growth of remnant nephrons...not surprising, well known in animal models of renal mass reduction that compensatory renal growth is blunted with age!
 
Nephrosclerosis associated reduction in nephron numbers is associated with compensatroy glomerular growth, that maintain total GFR; well thats good news and shows that compensatory growth and hyperfiltration are a good and not a bad thing...physiological rather than pathological as we were led to beleive...
 
Obesity and excessive height are associated with single nephron hyperfiltration...so what...?!
 
Overall, I failed to quite grasp the publication message,

 CAN SOMEBODY EXPLAINS ITS FINDINGS TO ME....?! 

Meguid El Nahas

Professor Meguid El Nahas PhD, FRCP

Chief Editor, OLA Director

Professor El Nahas was born in Cairo, Egypt and undertook his undergraduate medical education in...

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