OLA Blog

Efficacy and safety of BELIMUMAB in patients with active SLE (Lancet March 2011)

Written by Meguid El Nahas on Tuesday, 15 March 2011. Posted in OLA Blog

Efficacy and safety of BELIMUMAB in patients with active SLE (Lancet March 2011)
The paper in the Lancet (2011;377, 721) by Navarra et al. reports the outcome of a large, phase 3, clinical trial on the use of Belimumab (a human monoclonal antibody that blocks BLyS (B-lymphocyte stimulator) activity. Increased activity of B...

Erythropoiesis stimulating agents (ESAs) increase the risk of acute stroke in patients with CKD

Written by Meguid El Nahas on Monday, 14 March 2011. Posted in OLA Blog

Erythropoiesis stimulating agents (ESAs) increase the risk of acute stroke in patients with CKD
In this paper by Seliger and colleagues from Baltimore USA, the authors report an increased risk of stroke in CKD (mainly 3) who are using ESAs. This observational study of 12,426  patients individuals confirmed the previous observation made...

World Kidney Day 2011

Written by Meguid El Nahas on Tuesday, 08 March 2011. Posted in OLA Blog

World Kidney Day 2011
The World Kidney Day 2011 to be held on March the 11th has the Motto: Protect Your Kidneys, Save Your Heart stressing the important link between CKD and CVD. Editorials have appeared in all major Nephrology journals by Bill Couser and Miguel...

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Written by Meguid El Nahas on Monday, 21 February 2011. Posted in OLA Blog

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting
This article by Huang and colleagues from Taiwan appeared in the January 2011 issue of JASN. It shows that patients undergoing coronary artery grafting/surgery who have pre-operative proteinuria are at a considerable higher risk to develop...

Equations To Estimate Creatinine Excretion Rate: The CKD Epidemiology Collaboration.

Written by Meguid El Nahas on Sunday, 20 February 2011. Posted in OLA Blog

Equations To Estimate Creatinine Excretion Rate: The CKD Epidemiology Collaboration.
An article by Ix and colleagues in the January 2011 issue of CJASN describes new equations to calculate urine creatinine excretion rate. Urine creatinine excretion is increasingly relied upon to calculate the degree of proteinuria/albuminuria...

Prevention of Dialysis Catheter Malfunction with recombinant Tissue Plasminogen Activator

Written by Meguid El Nahas on Sunday, 20 February 2011. Posted in OLA Blog

Prevention of Dialysis Catheter Malfunction with recombinant Tissue Plasminogen Activator
This study by Hemmelgarn and colleagues (NEJM January 27, 2011) addresses the important issue of the prevention of dialysis central venous catheters infections. the authors studied a small number of patients (n=225) randomised to have either...

Chronic Kidney Disease and Cardiovascular Disease – SHARP Study

Written by arif khwaja on Monday, 24 January 2011. Posted in OLA Blog

Chronic Kidney Disease and Cardiovascular Disease – SHARP Study
Patients with Chronic Kidney Disease (CKD) are at much higher risk of cardiovascular disease than the general population but the benefits of lipid reduction in this population have been far from clear. Recent data from the Study of Heart and...

Daily Dialysis – a look into the future?

Written by arif khwaja on Monday, 24 January 2011. Posted in OLA Blog

Daily Dialysis – a look into the future?
The ‘long and slow’ approach to haemodialysis as advocated by the group from Tassin, France has yielded impressive results in terms of blood pressure control and patient survival. This has lead to increasing interest in daily...