OLA Blog

ADVANCE (NDT March 2011)

Written by Meguid El Nahas on Wednesday, 20 April 2011. Posted in OLA Blog

ADVANCE (NDT March 2011)
Raggi and collaborators hav ereported the results of the ADVANCE study on the effect of the calcimimetic Cinacalcet of cardiac calcifications; CAC and Valvular calcifications. This was a RCT comparing the combination of Cinacalcet + low dose...

CMV Vaccine (Lancet April 2011)

Written by Meguid El Nahas on Tuesday, 19 April 2011. Posted in OLA Blog

CMV Vaccine (Lancet April 2011)
A group of researchers from the Royal Free, London, headed by Prof Paul Griffiths have published the result of a phase 2, proof of concept, study on the efficacy of a cytomegalovirus glycoprotein-B protein vaccine in recipients of transplanted...

CUBN (Cubulin): A gene locus for Albuminuria (JASN March 2011)

Written by Meguid El Nahas on Tuesday, 19 April 2011. Posted in OLA Blog

CUBN (Cubulin): A gene locus for Albuminuria (JASN March 2011)
This genetic study relying of Genome wide association study (GWAS) showed an association between a missense variant in the CUBN gene, which encodes cubulin, and both albuminuria. This association was noted in the general population independently...

WCN Vancouver 2011 Day 4

Written by Meguid El Nahas on Tuesday, 12 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 4
A very interesting lecture by Professor Caroline Fox (USA) on the genetics of hypertension and CKD. Data derived from a number of genetic stduies consortia, including the CKD Gen, CHARGE and Global BP Gen, has explored gentic associations with...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Professor Neil Powe (USA) discussed the issue of healthcare disparities and inequalities in the USA where ethnic minorities have worse outcomes than Caucasians. he noted that by 2050, whites would be in a minority ( For instance most Black patients with CKD are seen clinics and emergency rooms where they have no follow-ups as most don't have healthcare insurance. Whites on the other hand tend to be referred early to private healthcare facilities where they...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Plenary lecture by Professor David Salant (USA) highlighting his discovery of the relevance of autoantibodies against the podocyte antigen M-type phospholipase A2 R, present on podocytes, to the pathogenesis of idiopathic membranous nephropathy...

Sugar Cane Nephropathy

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

Sugar Cane Nephropathy
Professor Ricardo Correa-Rotter from Mexico reviwed the issue of very high CKD and ESRD in central America. MesoAmerican Endemic Nephropathy. This has been attributed to a number of factors but more recently to involvements of those working in...

WCN Vancouver 2011 Day 2

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 2
Second plenary lecture by Prof Wendy Hoy (Australia) on the nephrological plight of Australian aborigines. Native australians are amongst the most deprived populations in the world. They suffer high morbidity and mortality rates. The incidence...

WCN vancouver 2011 Day 2

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

WCN vancouver 2011 Day 2
I attended two plenary lectures: The first by prof David Sacks on tolerance in renal transplantation. He highlighted the joruney related to research into induction of tolerance in recipients of allografts by T cell depletion followed by...

WCN Vancouver 2011 Opening Lecture

Written by Meguid El Nahas on Saturday, 09 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Opening Lecture
A truly spectacular lecture was given by Professor Douglas Wallace (Pennsylvania, USA) on mitochondrial disease and mtDNA mutations and their anthropological as well as medical implications. Professor Wallace explained hwo the mitochondria (an...