OLA Blog

Hepatitis C and Kidney Transplantation

Written by arif khwaja on Friday, 06 May 2011. Posted in OLA Blog

Hepatitis C and Kidney Transplantation
The recent KDIGO guidelines on Hepatitis C have provided clinicians with useful guidance on how to work up Hepatitis C positive dialysis patients for renal transplantaion. A single centre observational study from David Roth's group in Miami, USA...

Genetics and CKD (Nephron 2011)

Written by Meguid El Nahas on Friday, 06 May 2011. Posted in OLA Blog

Genetics and CKD (Nephron 2011)
Conall O’Seaghdha and Caroline Fox update readers  on data emerging from genomic wide associations studies (GWAS) linking a number of genes to the predisposition and progression of CKD. TCF7L2 gene polymorphism has been linked to increased...

Pirfenidone in Diabetic Nephropathy (JASN April 2011)

Written by Meguid El Nahas on Monday, 02 May 2011. Posted in OLA Blog

Pirfenidone in Diabetic Nephropathy (JASN April 2011)
Interesting pilot study on the effect of the anti-inflammatory agent pirfenidone in patient with diabetic nephropathy. The study shows that over 12 months low dose pirfenidone (1200mg/d) improved GFR compared to placebo and high dose (2400mg/d)....

Risk of ESRD in T1DM (JASN March 2011)

Written by Meguid El Nahas on Thursday, 21 April 2011. Posted in OLA Blog

Risk of ESRD in T1DM (JASN March 2011)
A paper by Rosolowsky et al from the Joslin Clinic in Boston reviews the incidence of ESRD in T1DM patients with macroalbuminuria over the last 15-20 years. Whilst ESRD risk increases with advancing stages of CKD, as expected.The incidence of...

ADVANCE (NDT March 2011)

Written by Meguid El Nahas on Wednesday, 20 April 2011. Posted in OLA Blog

ADVANCE (NDT March 2011)
Raggi and collaborators hav ereported the results of the ADVANCE study on the effect of the calcimimetic Cinacalcet of cardiac calcifications; CAC and Valvular calcifications. This was a RCT comparing the combination of Cinacalcet + low dose...

CMV Vaccine (Lancet April 2011)

Written by Meguid El Nahas on Tuesday, 19 April 2011. Posted in OLA Blog

CMV Vaccine (Lancet April 2011)
A group of researchers from the Royal Free, London, headed by Prof Paul Griffiths have published the result of a phase 2, proof of concept, study on the efficacy of a cytomegalovirus glycoprotein-B protein vaccine in recipients of transplanted...

CUBN (Cubulin): A gene locus for Albuminuria (JASN March 2011)

Written by Meguid El Nahas on Tuesday, 19 April 2011. Posted in OLA Blog

CUBN (Cubulin): A gene locus for Albuminuria (JASN March 2011)
This genetic study relying of Genome wide association study (GWAS) showed an association between a missense variant in the CUBN gene, which encodes cubulin, and both albuminuria. This association was noted in the general population independently...

WCN Vancouver 2011 Day 4

Written by Meguid El Nahas on Tuesday, 12 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 4
A very interesting lecture by Professor Caroline Fox (USA) on the genetics of hypertension and CKD. Data derived from a number of genetic stduies consortia, including the CKD Gen, CHARGE and Global BP Gen, has explored gentic associations with...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Professor Neil Powe (USA) discussed the issue of healthcare disparities and inequalities in the USA where ethnic minorities have worse outcomes than Caucasians. he noted that by 2050, whites would be in a minority ( For instance most Black patients with CKD are seen clinics and emergency rooms where they have no follow-ups as most don't have healthcare insurance. Whites on the other hand tend to be referred early to private healthcare facilities where they...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Plenary lecture by Professor David Salant (USA) highlighting his discovery of the relevance of autoantibodies against the podocyte antigen M-type phospholipase A2 R, present on podocytes, to the pathogenesis of idiopathic membranous nephropathy...