OLA Blog

Screening fo NPHS2 mutations may help predict FSGS recurrence after transplantation

Written by Meguid El Nahas on Saturday, 09 April 2011. Posted in OLA Blog

Screening fo NPHS2 mutations may help predict FSGS recurrence after transplantation
Jungraithmayr and colleagues in the March issue of JASN report the interesting observation that patients with FSGS and a SNP mutation in the NPHS2 gene coding for the podocyte protein (podocin) seem somewhat protected from NS and FSGS recurrence...

Aspirin and AV graft thrombosis

Written by arif khwaja on Monday, 04 April 2011. Posted in OLA Blog

Aspirin and AV graft thrombosis
Data from the DAC Graft Trial, in which 649 patients were assigned to either placebo or twice-daily extended-release dipyridamole (200 mg) and Aspirin (ASA) (25 mg; ERDP/ASA) after AV graft placement suggested that ERDP/ASA lead to a very...

Calcineurin inhibitors and long term outcomes

Written by arif khwaja on Thursday, 31 March 2011. Posted in OLA Blog

Calcineurin inhibitors and long term outcomes
A very thoughtful piece by Professor Chapman from Sydney, Australia in this months AJT reviewing the literature around CNI nephrotoxicity ( see here ) Professor Chapman confirms the notion that whilst CNIs reduce the incidence of acute...

eGFR - is CKD-EPI the way forward.

Written by arif khwaja on Monday, 21 March 2011. Posted in OLA Blog

eGFR - is CKD-EPI the way forward.
There is an interesting article in this months cJASN analysing the effect of using the CKD-EPI formula (rather than the MDRD equation) on eGFR calculation and therefore CKD diagnosis. The CKD-EPI formula is believed to be more accurate than MDRD...

Elderly Donors and organ transplantation

Written by arif khwaja on Thursday, 17 March 2011. Posted in OLA Blog

Elderly Donors and organ transplantation
Much of the growth in the UK in transplantation has come from increased use of liver donors. Increasingly elderly donors are being used. A single centre retrospective cohort study from Ontario, Canada suggests that at 4 years of follow up there...

Efficacy and safety of BELIMUMAB in patients with active SLE (Lancet March 2011)

Written by Meguid El Nahas on Tuesday, 15 March 2011. Posted in OLA Blog

Efficacy and safety of BELIMUMAB in patients with active SLE (Lancet March 2011)
The paper in the Lancet (2011;377, 721) by Navarra et al. reports the outcome of a large, phase 3, clinical trial on the use of Belimumab (a human monoclonal antibody that blocks BLyS (B-lymphocyte stimulator) activity. Increased activity of B...

Erythropoiesis stimulating agents (ESAs) increase the risk of acute stroke in patients with CKD

Written by Meguid El Nahas on Monday, 14 March 2011. Posted in OLA Blog

Erythropoiesis stimulating agents (ESAs) increase the risk of acute stroke in patients with CKD
In this paper by Seliger and colleagues from Baltimore USA, the authors report an increased risk of stroke in CKD (mainly 3) who are using ESAs. This observational study of 12,426  patients individuals confirmed the previous observation made...

World Kidney Day 2011

Written by Meguid El Nahas on Tuesday, 08 March 2011. Posted in OLA Blog

World Kidney Day 2011
The World Kidney Day 2011 to be held on March the 11th has the Motto: Protect Your Kidneys, Save Your Heart stressing the important link between CKD and CVD. Editorials have appeared in all major Nephrology journals by Bill Couser and Miguel...

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Written by Meguid El Nahas on Monday, 21 February 2011. Posted in OLA Blog

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting
This article by Huang and colleagues from Taiwan appeared in the January 2011 issue of JASN. It shows that patients undergoing coronary artery grafting/surgery who have pre-operative proteinuria are at a considerable higher risk to develop...

Equations To Estimate Creatinine Excretion Rate: The CKD Epidemiology Collaboration.

Written by Meguid El Nahas on Sunday, 20 February 2011. Posted in OLA Blog

Equations To Estimate Creatinine Excretion Rate: The CKD Epidemiology Collaboration.
An article by Ix and colleagues in the January 2011 issue of CJASN describes new equations to calculate urine creatinine excretion rate. Urine creatinine excretion is increasingly relied upon to calculate the degree of proteinuria/albuminuria...