OLA Blog

WCN Vancouver 2011 Day 4

Written by Meguid El Nahas on Tuesday, 12 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 4
A very interesting lecture by Professor Caroline Fox (USA) on the genetics of hypertension and CKD. Data derived from a number of genetic stduies consortia, including the CKD Gen, CHARGE and Global BP Gen, has explored gentic associations with...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Professor Neil Powe (USA) discussed the issue of healthcare disparities and inequalities in the USA where ethnic minorities have worse outcomes than Caucasians. he noted that by 2050, whites would be in a minority ( For instance most Black patients with CKD are seen clinics and emergency rooms where they have no follow-ups as most don't have healthcare insurance. Whites on the other hand tend to be referred early to private healthcare facilities where they...

WCN Vancouver 2011 Day 3

Written by Meguid El Nahas on Monday, 11 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 3
Plenary lecture by Professor David Salant (USA) highlighting his discovery of the relevance of autoantibodies against the podocyte antigen M-type phospholipase A2 R, present on podocytes, to the pathogenesis of idiopathic membranous nephropathy...

Sugar Cane Nephropathy

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

Sugar Cane Nephropathy
Professor Ricardo Correa-Rotter from Mexico reviwed the issue of very high CKD and ESRD in central America. MesoAmerican Endemic Nephropathy. This has been attributed to a number of factors but more recently to involvements of those working in...

WCN Vancouver 2011 Day 2

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Day 2
Second plenary lecture by Prof Wendy Hoy (Australia) on the nephrological plight of Australian aborigines. Native australians are amongst the most deprived populations in the world. They suffer high morbidity and mortality rates. The incidence...

WCN vancouver 2011 Day 2

Written by Meguid El Nahas on Sunday, 10 April 2011. Posted in OLA Blog

WCN vancouver 2011 Day 2
I attended two plenary lectures: The first by prof David Sacks on tolerance in renal transplantation. He highlighted the joruney related to research into induction of tolerance in recipients of allografts by T cell depletion followed by...

WCN Vancouver 2011 Opening Lecture

Written by Meguid El Nahas on Saturday, 09 April 2011. Posted in OLA Blog

WCN Vancouver 2011 Opening Lecture
A truly spectacular lecture was given by Professor Douglas Wallace (Pennsylvania, USA) on mitochondrial disease and mtDNA mutations and their anthropological as well as medical implications. Professor Wallace explained hwo the mitochondria (an...

Screening fo NPHS2 mutations may help predict FSGS recurrence after transplantation

Written by Meguid El Nahas on Saturday, 09 April 2011. Posted in OLA Blog

Screening fo NPHS2 mutations may help predict FSGS recurrence after transplantation
Jungraithmayr and colleagues in the March issue of JASN report the interesting observation that patients with FSGS and a SNP mutation in the NPHS2 gene coding for the podocyte protein (podocin) seem somewhat protected from NS and FSGS recurrence...

Aspirin and AV graft thrombosis

Written by arif khwaja on Monday, 04 April 2011. Posted in OLA Blog

Aspirin and AV graft thrombosis
Data from the DAC Graft Trial, in which 649 patients were assigned to either placebo or twice-daily extended-release dipyridamole (200 mg) and Aspirin (ASA) (25 mg; ERDP/ASA) after AV graft placement suggested that ERDP/ASA lead to a very...

Calcineurin inhibitors and long term outcomes

Written by arif khwaja on Thursday, 31 March 2011. Posted in OLA Blog

Calcineurin inhibitors and long term outcomes
A very thoughtful piece by Professor Chapman from Sydney, Australia in this months AJT reviewing the literature around CNI nephrotoxicity ( see here ) Professor Chapman confirms the notion that whilst CNIs reduce the incidence of acute...