OLA Blog

To Treat or Not to Treat...?!

Written by Meguid El Nahas on Monday, 26 June 2017. Posted in OLA Blog

To Treat or Not to Treat...?!
https://www.thetimes.co.uk/article/professor-marcel-levi-dying-should-shun-treatment-and-take-final-holiday-pvsbkv0wj?shareToken=79a3e1f73a909362cfe132ca0b22a9ae Professor Marcel Levi: Dying should shun treatment and take final holiday......

More or Less Nephrons...

Written by Meguid El Nahas on Thursday, 22 June 2017. Posted in OLA Blog

More or Less Nephrons...
I read more than once this paper and failed to understand it... N Engl J Med. 2017 Jun 15;376(24):2349-2357. doi: 10.1056/NEJMoa1614329. Single-Nephron Glomerular Filtration Rate in Healthy Adults. Denic A1, Mathew...

PRECISION MEDICINE: Whats in a Name?!

Written by Meguid El Nahas on Tuesday, 30 May 2017. Posted in OLA Blog

PRECISION MEDICINE: Whats in a Name?!
PRECISION MEDICINE, a term that has crept into the medical lexicom that baffles me... I am told that PRECISION MEDICINE is: "...based on accurate diagnosis and tailored interventions through the use of improved diagnostic tests and clinical...

Precision Nephrology in Genomic Era

Written by Neveen A Soliman on Sunday, 28 May 2017. Posted in OLA Blog

Precision Nephrology in Genomic Era
Chronic Kidney Disease (CKD) is a major global health problem with significant morbidity and mortality and high economic burden in various geographic communities. During the 20th century, nephrology clinical practice witnessed significant...

RCTs in CKDs: A Waste of Time?

Written by Meguid El Nahas on Sunday, 21 May 2017. Posted in OLA Blog

RCTs in CKDs: A Waste of Time?
Many Nephrologists seem preoccupied by planning randomised control trials (RCTs) to slow the progression of CKD (Chronic Kidney Disease)... What a folly...!!!! As if CKD is a disease...it is a simplified definition of reduced kidney function...

Cystic Kidney Diseases

Written by Neveen A Soliman on Saturday, 20 May 2017. Posted in OLA Blog

Figure 1. Renal ultrasound scans of: (a) ARPKD; (b) ADPKD; (c) Juvenile NPHP; (d) Bilateral cystic dysplastic kidneys
Clinical and ultrasonographical characterization of childhood cystic kidney diseases in Egypt Ren Fail. 2014 Jun;36(5):694-700. doi: 10.3109/0886022X.2014.883996 http://www.tandfonline.com/doi/full/10.3109/0886022X.2014.883996 From authors...

Is KI Fit for Purpose?

Written by Meguid El Nahas on Monday, 15 May 2017. Posted in OLA Blog

Is KI Fit for Purpose?
        I read this month (May 2017) Kidney International whilst in an emerging country teaching to emerging doctors on clinical aspects of Kidney Disease. Once more, I found very few articles of relevance to those...

This Month (May 2017) in KI: Obesity and CKD

Written by Meguid El Nahas on Monday, 15 May 2017. Posted in OLA Blog

This Month (May 2017) in KI: Obesity and CKD
Obesity and new onset of CKD: https://www.ncbi.nlm.nih.gov/pubmed/28187985 Obesity but not overweight increases risk of CKD (eGFR <60 and albuminuria) in the general population. A systematic review and Meta-analysis of 39 cohorts, 630,677...

Last Month in Nephrology...by Prof Tukaram Jamale

Written by Meguid El Nahas on Friday, 05 May 2017. Posted in OLA Blog

Last Month in Nephrology...by Prof Tukaram Jamale
April-May 2017 JASN  Pregnancy outcomes in recovered AKI  In a study of 105 pregnancies classified as rAKI (pregnant women with history of recovered AKI) were compared with 24640 control pregnancies-authors noted that...

Epigenetic modifications in ANCA-associated vasculitis (AAV)

Written by Neveen A Soliman on Wednesday, 05 April 2017. Posted in OLA Blog

Epigenetic modifications in ANCA-associated vasculitis (AAV)
AAV is a relapsing and remitting autoimmune disease characterized by vascular inflammation and organ damage. -       Generally characterized by circulating ANCA, reactive to proteinase 3 (PR3) or myeloperoxidase...