OLA Blog

NGAL and CVD: Blinkers off!

Written by Meguid El Nahas on Monday, 20 October 2014. Posted in OLA Blog

NGAL and CVD: Blinkers off!
Am J Kidney Dis. 2014 Oct 10. pii: S0272-6386(14)01163-9. doi: 10.1053/j.ajkd.2014.07.025. [Epub ahead of print] Urine Neutrophil Gelatinase-Associated Lipocalin and Risk of Cardiovascular Disease and Death in CKD: Results From the Chronic...

DIALYSIS CATHETER THROMBOSES

Written by Nick Fardon on Friday, 17 October 2014. Posted in OLA Blog

DIALYSIS CATHETER THROMBOSES
By Dr NICHOLAS FARDON, CONSULTANT RENAL PHYSICIAN AT THE SHEFFIELD KIDNEY INSTITUTE, SHEFFIELD, UK: SHARING HIS EXPERIENCE OF > 2000 TUNELLED DIALYSIS CATHETERS, RELATED TO CATHETERS THROMBOSES: A few questions I would ask myself first: * Is...

MORE ON GUIDELINES AND THEIR ADVISORY PANELS....

Written by Meguid El Nahas on Friday, 05 September 2014. Posted in OLA Blog

MORE ON GUIDELINES AND THEIR ADVISORY PANELS....
BMJ 2014;349:g5448 doi: 10.1136/bmj.g5448 (Published 4 September 2014)  How guidelines can fail usFiona Godlee editor in chief, The BMJShould patients be offered β blockers if they have ischaemicheart disease and are about to undergo...

RELAPSE OF IMN AFTER TRANSPLANTATION

Written by Meguid El Nahas on Tuesday, 02 September 2014. Posted in OLA Blog

RELAPSE OF IMN AFTER TRANSPLANTATION
Nephrol Dial Transplant. 2014 Jul 25. pii: gfu252. [Epub ahead of print] Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of...

Duplication in Nephrology Publications

Written by Meguid El Nahas on Thursday, 28 August 2014. Posted in OLA Blog

Duplication in Nephrology Publications
SHARP Study GRoup.   The SHARP study group showed in their original publication that lipids lowering with a combination of simvastatin and ezetimibe had little effect on overall or cardiovascular mortality in CKD. They also showed that...

Short termism in Nephrology Publications...

Written by Meguid El Nahas on Thursday, 21 August 2014. Posted in OLA Blog

Short termism in Nephrology Publications...
It strikes that Nephrologists are so keen to publish theat they often publish short term, incomplete, underpowered and inaccurate informations...that shape our practice. Two recent examples, in ANCA associated systemic vasculitis (AASV): We wre...

PURE Confusion

Written by Meguid El Nahas on Friday, 15 August 2014. Posted in OLA Blog

PURE Confusion
Two articles have been published this month in the NEJM relating to the PURE study outcomes: N Engl J Med. 2014 Aug 14;371(7):601-11. doi: 10.1056/NEJMoa1311989.  and  N Engl J Med. 2014 Aug 14;371(7):612-23. doi:...

BE SMART ON SHARP!

Written by Meguid El Nahas on Friday, 15 August 2014. Posted in OLA Blog

BE SMART ON SHARP!
J Am Soc Nephrol. 2014 Aug;25(8):1825-33. doi: 10.1681/ASN.2013090965. Epub 2014 May 1.   This publication from the SHARP study group showed NO EFFECT of STATINS on the PROGRESSION OF CKD. COMMENTS: So the SHARP study is also...

NEPHROLOGY 40 YEARS ON: NIHILISTIC OR REALISTIC?

Written by Meguid El Nahas on Tuesday, 05 August 2014. Posted in OLA Blog

NEPHROLOGY 40 YEARS ON: NIHILISTIC OR REALISTIC?
I have been practicing Medicine and Nephrology for 40 years. It occured to me that true and major breakthroughs in the management of CKD have been few and far between during these 40-50 years. In fact, when I started practicing Nephrology and...

Alemtuzumab in transplantation - the 3C study

Written by arif khwaja on Friday, 01 August 2014. Posted in OLA Blog

Alemtuzumab in transplantation - the 3C study
The 3C study presented at this weeks’ World Transplant Congress and published online in the Lancet is an important study, which may in the future inform clinical practice in transplantation. In essence there are two parts to the study. The...