OLA Blog

IGAN: STOP TESTING...

Written by Meguid El Nahas on Tuesday, 24 May 2016. Posted in OLA Blog

IGAN: STOP TESTING...
An growing controversy is buidling around the use of steroids in IgA Nephropathy. Pozzi and Locatelli showed that high dose steroids slow the progression of the nephropathy. http://www.ncbi.nlm.nih.gov/pubmed/10093981 The large STOPIGAN...

Is fetal environment linked to hypertension and CVD in the adult?

Written by Neveen A Soliman on Friday, 13 May 2016. Posted in OLA Blog

Is fetal environment linked to hypertension and CVD in the adult?
Two decades ago, Hales and Barker reported the association between hypertension (HTN) in adult life and birth weight. They suggested that intrauterine environmental factors, mainly nutrition, could lead to permanent metabolic and structural...

PPI, Not for I....?!

Written by Meguid El Nahas on Monday, 09 May 2016. Posted in OLA Blog

PPI, Not for I....?!
J Am Soc Nephrol. 2016 Apr 14. pii: ASN.2015121377. [Epub ahead of print] Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD. Xie Y1, Bowe B1, Li T2, Xian H3, Balasubramanian...

MAREMAR STUDY: HOW CKD EPIDEMIOLOGY SHOULD BE CONDUCTED!

Written by Meguid El Nahas on Monday, 25 April 2016. Posted in OLA Blog

MAREMAR STUDY: HOW CKD EPIDEMIOLOGY SHOULD BE CONDUCTED!
MAREMAR STUDY: CKD CLASSIFICATION, TIME TO RE-THINK?   https://www.researchgate.net/publication/297892002_Maremar_prevalence_of_chronic_kidney_disease_how_to_avoid_over-diagnosis_and_under-diagnosis   The MAREMAR study of CKD...

Obesity and Diabetes: A Myth?

Written by Meguid El Nahas on Sunday, 24 April 2016. Posted in OLA Blog

Obesity and Diabetes: A Myth?
http://www.ncbi.nlm.nih.gov/pubmed/27061677 The latest analysis by the Non-Communicable Disease worldwide collaboration gives an intriguing picture of the prevalence of Diabetes Mellitus (DM) worldwide. Age-standardised prevalence, shows: NO...

A CKD CLASSIFICATION FOR ALL AGES!?

Written by Meguid El Nahas on Wednesday, 13 April 2016. Posted in OLA Blog

A CKD CLASSIFICATION FOR ALL AGES!?
http://www.ncbi.nlm.nih.gov/pubmed/27057075 This excellent paper proposes an age-sensitive CKD classification: <40 years: CKD threshold = 75 ml/min 40-65years: CKD threshold = 60 ml/min >65 years: CKD threshold =45 ml/min this in the...

ARE SCIENTIFIC JOURNALS FIT FOR PURPOSE?

Written by Meguid El Nahas on Sunday, 10 April 2016. Posted in OLA Blog

ARE SCIENTIFIC JOURNALS FIT FOR PURPOSE?
This is an interesting blog by Dr Ben Goldacre who basically is arguing that academic journals are effectively not a 'fit for purpose' arena to publish results of clinical trials.   He also makes the point that the usually impossible to get...

HLA incompatible live transplantation

Written by arif khwaja on Friday, 08 April 2016. Posted in OLA Blog

HLA incompatible live  transplantation
Whilst the benefits of transplantation are well established, finding suitable donors for ‘sensitised’ patients with anti-HLA antibodies remains a significant barrier to transplantation. The options for such patients are to stay on the...

Thrombotic Microangiopathies

Written by Neveen A Soliman on Tuesday, 29 March 2016. Posted in OLA Blog

Thrombotic Microangiopathies
  Enormous advances continue to be made to enhance our understanding of the challenging “thrombotic microangiopathies TMA” It is becoming clear, recently, that distinct disease mechanisms underlie the group of diseases formerly...

No Profit...No CKD...

Written by Meguid El Nahas on Monday, 14 March 2016. Posted in OLA Blog

No Profit...No CKD...
I received this letter from a US Nephrologist working in non fee for service environment... revealing! Hello Professor Meguid El Nahas,  I saw your article in Jama from August 2015, regarding CKD...